Oedema during Macrocytic Anaemia

Macrocytic anaemia in patients treated with sulfasalazine for rheumatoid arthritis.

Sulphasalazine is a "disease modifying" drug that is now widely used in rheumatoid arthritis, having fewer and milder side effects than gold or penicillamine.' One potential side effect, which is easily missed and may become life threatening, is macrocytic anaemia. This occurs in 2-3% of prising and possibly to "reflect the brittle state of folate metabolism in rheumatoid arthritis." Since then...

Anisocytosis and the C-1000 Channelyzer in macrocytic anaemia.

Red cell anisocytosis as assessed using the Coulter Channelyzer C-1000 showed an increase with progressive anaemia in 25 patients with macrocytosis due to B12 and/or folate deficiency. In deficiency of a single factor, the degree of anisocytosis increased with progressive anaemia. In five cases with B12 and folate deficiency combined, anisocytosis was markedly increased out of proportion to the...

Two Causes for Macrocytic Anaemia in One Patient

Dr. O. C. Lloyd: Our first case was in Southmead Hospital under the care of DrNaish, who is at present abroad, and Dr. Mehta has very kindly come to give us the clinical story. Dr. S. H. Mehta: A housewife aged 51 was first seen by Dr. Naish when she was admitted under the care of Dr. Warin for recurrent gravitational ulcers on both her legs in May i960. By then she had been attending dermatolo...

Role of NEUT-X & NEUT-Y in picking up megaloblastic anaemia on peripheral blood & in differentiating from other macrocytic anaemia

Macrocytic anaemia due to copper deficiency in a patient with late onset hypogammaglobulinaemia.

Very few cases of acquired severe copper deficiency have been described. The principal effects are haematological, but the precise abnormalities are uncertain due to the possible association of other deficiencies. A case of isolated severe copper deficiency associated with late onset hypogammaglobulinaemia is reported in which the chief findings were macrocytic anaemia, neutropenia and a decrea...